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First-in-Class Hair Cycle Stimulators for the Treatment of Alopecia of Various Causes

 

BiologicsMD has three programs focused on restoring hair growth and preventing hair loss by stimulating receptors at the hair follicle in conditions of alopecia areata, androgenetic alopecia, and chemotherapy-induced alopecia.

These compounds are fusion proteins with an Active Domain (parathyroid hormone agonist) coupled to a Binding Domain that targets Type I collagen. The Active Domain is designed to stimulate the hair follicles and restore hair growth while the Binding Domain targets and retains the treatment in the skin for a localized and sustained response with limited off-target effects. This novel mechanism of action has been shown to promote hair growth more effectively and without the serious side effects of existing treatments in animal models of alopecia, and does so with dosing as infrequent as once every 1 to 6 months.